Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25695874 | 0.97 | CDK8 (0.49) | CDK8CLK4APPKDM4EATM | |
| SCHEMBL21498140 | 0.92 | CDK8 (0.49) | CDK8CLK4APPKDM4EATM | |
| SCHEMBL21498148 | 0.87 | CDK8 (0.42) | CDK8CLK4APPKDM4EATM | |
| SCHEMBL11654613 | 0.79 | KDM4E (0.65) | KDM4EATMPOLBKMT2ACA12 | |
| SCHEMBL21498146 | 0.78 | MAPT (0.45) | APPKDM4EHDAC3HDAC1HDAC2 | |
| SCHEMBL7175921 | 0.77 | PLAAT3 (0.54) | KDM4EATMPOLBHDAC3HDAC1 | |
| SCHEMBL28549332 | 0.77 | SLC2A1 (0.67) | KDM4EATMPOLBKMT2ACA12 | |
| SCHEMBL11934971 | 0.77 | SLC2A1 (0.67) | KDM4EATMPOLBKMT2ACA12 | |
| SCHEMBL10518881 | 0.76 | KDM4E (0.65) | KDM4EATMPOLBKMT2ACA12 | |
| SCHEMBL21498147 | 0.75 | ELANE (0.52) | KDM4EPOLBHDAC3HDAC2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10449167-B2 | Polyamine derivative medicinal salt and preparation method and use | Chongqing Antixin Biotechnology Co., LTD. (CN) | 2019-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10449167-B2 | Polyamine derivative medicinal salt and preparation method and use | SRM, TLR9, SELP | CDK8 3852/4885CLK4 1422/4885APP 3986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.