Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.54 |
| ▸ | TP53 | P04637 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050870 | 0.88 | SMN1; SMN2 (0.65) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL21499877 | 0.84 | GAA (0.66) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL21497112 | 0.84 | SMN1; SMN2 (0.56) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL21499903 | 0.84 | GAA (0.47) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL21499915 | 0.83 | GAA (0.45) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL3058473 | 0.83 | MAPT (0.48) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL21497180 | 0.82 | TP53 (0.54) | MAPTTP53SMN1; SMN2POLBCCR2 | |
| SCHEMBL21499889 | 0.81 | EPHX2 (0.50) | MAPTTP53SMN1; SMN2POLBGAA | |
| SCHEMBL21499912 | 0.81 | GAA (0.48) | MAPTTP53SMN1; SMN2GAARECQL | |
| SCHEMBL17249531 | 0.81 | GAA (0.66) | MAPTTP53SMN1; SMN2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159248-A1 | RE-SENSITIZING MULTIDRUG-RESISTANT (MDR) GRAM-NEGATIVE BACTERIA TO COLISTIN USING IONOPHORES | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2023-08-24 | — | — | WO | disclosed |
| US-20210253594-A1 | OXADIAZOLOPYRAZINES AND OXADIAZOLOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| US-20210253594-A1 | OXADIAZOLOPYRAZINES AND OXADIAZOLOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2021-08-19 | — | — | US | disclosed |
| WO-2019204813-A1 | OXADIAZOLOPYRAZINES AND OXADIAZOLOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253594-A1 | OXADIAZOLOPYRAZINES AND OXADIAZOLOPYRIDINES USEFUL AS MITOCHONDRIAL UNCOUPLERS | NDUFAF1, OXA1L, GLS2 | MAPT 4454/4885TP53 2822/4885SMN1; SMN2 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.