Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | TP53 | P04637 | 6/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17249531 | 0.92 | GAA (0.66) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL21499795 | 0.88 | MAPT (0.54) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL3060967 | 0.86 | MAPT (0.56) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL21499958 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL3050610 | 0.81 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL3063324 | 0.81 | GAA (0.76) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL31237749 | 0.81 | GAA (0.53) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL5025862 | 0.81 | MAPT (0.51) | SMN1; SMN2MAPTTP53POLBMEN1 | |
| SCHEMBL3051396 | 0.80 | TP53 (0.55) | SMN1; SMN2MAPTTP53POLBGAA | |
| SCHEMBL3051333 | 0.80 | MAPT (0.54) | SMN1; SMN2MAPTTP53POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178754-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2012-07-12 | — | — | US | claimed |
| US-20100222356-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2010-09-02 | — | — | US | claimed |
| US-20090131445-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2009-05-21 | — | — | US | claimed |
| EP-1799689-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | Compass Pharmaceuticals LLC (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006044402-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | COMPASS PHARMACEUTICALS LLC (US) | 2006-04-27 | — | — | WO | claimed |
| EP-3630115-B1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIV VIRGINIA PATENT FOUNDATION (US) | 2025-12-10 | — | — | EP | disclosed |
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2024-02-13 | — | — | US | disclosed |
| WO-2023159248-A1 | RE-SENSITIZING MULTIDRUG-RESISTANT (MDR) GRAM-NEGATIVE BACTERIA TO COLISTIN USING IONOPHORES | THE REGENTS OF THE UNIVERSITY OF COLORADO A BODY CORPORATE (US) | 2023-08-24 | — | — | WO | disclosed |
| US-20220017537-A1 | COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTATSIS AND INSULIN ACTION | UNIV VIRGINIA PATENT FOUNDATION (US) | 2022-01-20 | — | — | US | disclosed |
| US-11066415-B2 | Compositions and methods for regulating glucose homeostasis and insulin action | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200369683-A1 | COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION | UNIVERSITY OF VIRGINIA | 2020-11-26 | — | — | US | disclosed |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) | 2020-10-15 | — | — | US | disclosed |
| US-8785452-B2 | Anti-infective compounds | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2014-07-22 | — | — | US | disclosed |
| US-20120178754-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2012-07-12 | — | — | US | disclosed |
| US-20110178077-A1 | Anti-infective compounds | INSTITUT PASTEUR KOREA (KR) | 2011-07-21 | — | — | US | disclosed |
| US-20110178077-A1 | Anti-infective compounds | INSTITUT PASTEUR KOREA (KR) | 2011-07-21 | — | — | US | disclosed |
| US-20100222356-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2010-09-02 | — | — | US | disclosed |
| US-20090131445-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | COMPASS PHARMACEUTICALS LLC (US) | 2009-05-21 | — | — | US | disclosed |
| EP-1799689-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | Compass Pharmaceuticals LLC (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044402-A1 | FURAZANO `3, 4-B ! PYRAZYNES AND THEIR USE AS ANTI-TUMOR AGENTS | COMPASS PHARMACEUTICALS LLC (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066415-B2 | Compositions and methods for regulating glucose homeostasis and insulin action | GPR119, GLS, IRS1 | SMN1; SMN2 2902/4885MAPT 4551/4885TP53 3917/4885 |
| US-20100222356-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | CDC73, VHL, RB1 | SMN1; SMN2 243/4885MAPT 3908/4885TP53 4/4885 |
| US-20200369683-A1 | COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION | GPR119, GLS, IRS1 | SMN1; SMN2 2902/4885MAPT 4551/4885TP53 3917/4885 |
| US-20090131445-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | CDC73, RB1, CA5A | SMN1; SMN2 247/4885MAPT 4220/4885TP53 6/4885 |
| US-20120178754-A1 | Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents | CDC73, VHL, RB1 | SMN1; SMN2 243/4885MAPT 3908/4885TP53 4/4885 |
| US-11896591-B2 | Compositions and methods for preparing and using mitochondrial uncouplers | ACAD9, GPR119, NDUFAF1 | SMN1; SMN2 334/4885MAPT 3834/4885TP53 3537/4885 |
| US-20200323846-A1 | COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS | ACAD9, GPR119, NDUFAF1 | SMN1; SMN2 334/4885MAPT 3834/4885TP53 3537/4885 |
| US-20110178077-A1 | Anti-infective compounds | RABGGTB, ELANE, SERPINB1 | SMN1; SMN2 4839/4885MAPT 2660/4885TP53 2233/4885 |
| US-20220017537-A1 | COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTATSIS AND INSULIN ACTION | GPR119, GLS, IRS1 | SMN1; SMN2 3083/4885MAPT 4609/4885TP53 4255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.