Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LPL | P06858 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1561011 | 0.96 | HIF1A (0.47) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL16468330 | 0.92 | HIF1A (0.48) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL12224621 | 0.87 | HIF1A (0.45) | HIF1AAAK1L3MBTL1RECQLLIPG | |
| SCHEMBL20061080 | 0.84 | AAK1 (0.46) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL2151494 | 0.84 | AAK1 (0.59) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL25405585 | 0.82 | LPL (0.53) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL428836 | 0.82 | LPL (0.53) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL428838 | 0.82 | LPL (0.53) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL430495 | 0.82 | LPL (0.53) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL22816055 | 0.82 | MTNR1A (0.58) | HIF1AAAK1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774804-A1 | N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)BENZAMIDE DERIVATIVES | Novartis AG (CH) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019186343-A1 | N-(3-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PHENYL)BENZAMIDE DERIVATIVES | NOVARTIS AG (CH) | 2019-10-03 | — | — | WO | disclosed |
| WO-2011091086-A1 | NOVEL REAGENTS FOR DIRECTED BIOMARKER SIGNAL AMPLIFICATION | SIRIGEN INC. (US) | 2011-07-28 | — | — | WO | disclosed |