Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21500527 | 0.87 | HDAC11 (0.63) | HDAC11HDAC6 | |
| SCHEMBL21496713 | 0.79 | HDAC11 (0.77) | HDAC11HDAC6 | |
| SCHEMBL30039411 | 0.79 | HDAC11 (0.77) | HDAC11HDAC6 | |
| SCHEMBL21500532 | 0.74 | HDAC11 (0.46) | HDAC11HDAC6TIPARP | |
| SCHEMBL21496714 | 0.72 | HDAC11 (0.52) | HDAC11HDAC6 | |
| SCHEMBL21500452 | 0.68 | HDAC11 (0.41) | HDAC11TIPARP | |
| SCHEMBL21500519 | 0.68 | HDAC11 (0.63) | HDAC11 | |
| SCHEMBL21500450 | 0.65 | HDAC11 (1.00) | HDAC11HDAC6 | |
| SCHEMBL30038158 | 0.65 | HDAC11 (1.00) | HDAC11HDAC6 | |
| SCHEMBL21500518 | 0.65 | HDAC11 (0.44) | HDAC11TIPARP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |