Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.64 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.64 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.54 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.54 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.54 |
| ▸ | TDP2 | O95551 | 3/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RARA | P10276 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189494 | 0.86 | GRIA1 (0.60) | GRIA1CACNG8CRBNPDE3BPDE3A | |
| SCHEMBL21517866 | 0.85 | TDP2 (0.53) | GRIA1CACNG8CRBNTDP2PDE3B | |
| SCHEMBL688890 | 0.82 | TDP2 (0.61) | TDP2PDE3BPDE3AEPHX2SMYD3 | |
| SCHEMBL21533130 | 0.80 | GRIA1 (0.68) | GRIA1CACNG8CRBNPDE3BPDE3A | |
| SCHEMBL18189364 | 0.80 | GRIA1 (0.68) | GRIA1CACNG8CRBNTDP2PDE3B | |
| SCHEMBL6215760 | 0.79 | TDP2 (0.71) | GRIA1CACNG8CRBNTDP2PDE3B | |
| SCHEMBL10714302 | 0.78 | GRIA1 (1.00) | GRIA1CACNG8CRBNTDP2PDE3B | |
| SCHEMBL18189376 | 0.77 | GRIA1 (0.64) | GRIA1CACNG8CRBNPDE3BPDE3A | |
| SCHEMBL21517849 | 0.76 | GRIA1 (0.62) | GRIA1CACNG8CRBNTDP2PDE3B | |
| SCHEMBL4516470 | 0.74 | RXRA (0.51) | GRIA1GRIK1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | claimed |