Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.55 |
| ▸ | CACNG8 | Q8WXS5 | 3/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189346 | 0.86 | GRIA1 (0.54) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21517849 | 0.85 | GRIA1 (0.62) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21517845 | 0.82 | GRIA1 (0.60) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21517842 | 0.82 | GRIA1 (0.55) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL18189315 | 0.81 | GRIA1 (0.75) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL7076084 | 0.78 | GRIA1 (0.63) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL18189534 | 0.78 | PGR (0.56) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL18189304 | 0.78 | PGR (0.56) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21517847 | 0.78 | GRIA1 (0.76) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL28639586 | 0.77 | GRIA1 (0.69) | PGRGRIA1CACNG8BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | claimed |