Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31259949 | 0.86 | CYP11B2 (0.57) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL14789821 | 0.86 | CYP11B2 (0.57) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL14778457 | 0.84 | CYP11B1 (0.62) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL14779040 | 0.79 | CYP11B2 (0.58) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL31259980 | 0.78 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL14789897 | 0.78 | CYP11B1 (0.48) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL21518691 | 0.78 | CYP11B2 (0.61) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL22005295 | 0.77 | CYP11B1 (0.67) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL1119377 | 0.77 | CYP11B1 (1.00) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A | |
| SCHEMBL1119981 | 0.76 | CYP11B1 (0.72) | CYP11B1CYP11B2CYP1A2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755963-B1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2019-10-30 | — | — | EP | claimed |
| US-20160193212-A1 | CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR | AUSPEX PHARMACEUTICALS INC (US) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160193212-A1 | CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR | P2RY12, P2RY11, P2RY2 | CYP11B1 1089/4885CYP11B2 1068/4885CYP1A2 1578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.