Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	ALDH1A1	P00352	2/20	0.41

▸	CYP1A2	P05177	1/20	0.41

▸	CYP3A4	P08684	1/20	0.41

▸	CYP2C19	P33261	1/20	0.41

▸	KMT2A	Q03164	3/20	0.40

▸	MEN1	O00255	2/20	0.40

▸	PDE4A	P27815	1/20	0.40

▸	PDE4B	Q07343	1/20	0.40

▸	PDE4C	Q08493	1/20	0.40

▸	PDE4D	Q08499	1/20	0.40

▸	RECQL	P46063	1/20	0.40

▸	HTT	P42858	2/20	0.39

▸	CDK8	P49336	1/20	0.39

▸	NTRK3	Q16288	1/20	0.39

▸	SMN1; SMN2	Q16637	2/20	0.39

▸	LMNA	P02545	2/20	0.37

▸	KDM4E	B2RXH2	1/20	0.37

▸	POLB	P06746	1/20	0.37

▸	PTBP1	P26599	1/20	0.37

▸	TDP1	Q9NUW8	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL21519597	0.92	KMT2A (0.42)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Acetic Acid SCHEMBL21519528	0.86	MAPT (0.46)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Acetic Acid SCHEMBL21519518	0.85	KMT2A (0.46)	ALDH1A1CYP1A2CYP2C19KMT2AMEN1
SCHEMBL17044418	0.84	ALDH1A1 (0.43)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
SCHEMBL17044417	0.84	ALDH1A1 (0.43)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Hydrochloric Acid SCHEMBL6521087	0.83	ALDH1A1 (0.43)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Hydrochloric Acid SCHEMBL6521088	0.83	ALDH1A1 (0.43)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Acetic Acid SCHEMBL21519644	0.78	MAPT (0.49)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Acetic Acid SCHEMBL21519404	0.78	CYP1A2 (0.54)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A
Acetic Acid SCHEMBL21519524	0.77	MAPT (0.49)	ALDH1A1CYP1A2CYP3A4CYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-12006294-B2	Therapeutic compounds	REGENTS OF THE UNIVERSITY OF MINNESOTA (US)	2024-06-11	—	—	US	disclosed
US-20190330157-A1	THERAPEUTIC COMPOUNDS	REGENTS OF THE UNIVERSITY OF MINNESOTA	2019-10-31	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20190330157-A1	THERAPEUTIC COMPOUNDS	OPRL1, INA, OGFR	ALDH1A1 1048/4885CYP1A2 1407/4885CYP3A4 1976/4885
US-12006294-B2	Therapeutic compounds	OPRL1, INA, OGFR	ALDH1A1 1048/4885CYP1A2 1407/4885CYP3A4 1976/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.