Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanabenz SCHEMBL31129061 | 0.91 | POLB (0.53) | POLBHTTNPSR1KMT2AMEN1 | |
| SCHEMBL21519622 | 0.90 | HTT (0.48) | POLBHTTNPSR1KMT2AMEN1 | |
| Guanabenz SCHEMBL21519448 | 0.86 | CYP1A2 (0.49) | POLBHTTNPSR1KMT2AMEN1 | |
| Guanabenz SCHEMBL21519579 | 0.80 | KMT2A (0.47) | POLBHTTNPSR1KMT2AMEN1 | |
| Guanabenz SCHEMBL6302549 | 0.80 | POLB (0.57) | POLBHTTNPSR1KMT2AMEN1 | |
| Guanabenz SCHEMBL4103258 | 0.80 | POLB (0.57) | POLBHTTNPSR1KMT2AMEN1 | |
| Guanabenz SCHEMBL15389 | 0.80 | POLB (0.57) | POLBHTTNPSR1KMT2AMEN1 | |
| Acetic Acid SCHEMBL21519641 | 0.79 | NPSR1 (0.53) | POLBHTTNPSR1KMT2AMEN1 | |
| Acetic Acid SCHEMBL21519631 | 0.79 | KDM1A (0.49) | POLBHTTNPSR1KMT2AMEN1 | |
| Guanabenz SCHEMBL22616213 | 0.79 | POLB (0.55) | POLBHTTNPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12006294-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2024-06-11 | — | — | US | disclosed |
| US-20190330157-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190330157-A1 | THERAPEUTIC COMPOUNDS | OPRL1, INA, OGFR | POLB 4376/4885HTT 766/4885NPSR1 82/4885 |
| US-12006294-B2 | Therapeutic compounds | OPRL1, INA, OGFR | POLB 4376/4885HTT 766/4885NPSR1 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.