SCHEMBL2152111

SCHEMBL2152111

Cn1nc(C(=O)O)cc1O

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 9/20 0.41
HCAR3 P49019 1/20 0.41
DAO P14920 1/20 0.41
KDM4E B2RXH2 2/20 0.40
GRN P28799 1/20 0.40
SORT1 Q99523 1/20 0.40
BAZ2B Q9UIF8 1/20 0.40
ALDH1A1 P00352 3/20 0.39
APOBEC3A P31941 2/20 0.38
APOBEC3G Q9HC16 1/20 0.38
POLB P06746 1/20 0.38
GAA P10253 1/20 0.38
RPA1 P27694 1/20 0.37
ALOX15 P16050 1/20 0.37
TSHR P16473 1/20 0.37
HIF1A Q16665 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17522579 0.83 BAZ2B (0.40) KDM4EGRNSORT1BAZ2BALDH1A1
SCHEMBL4751927 0.81 PLA2G10 (0.49) KDM4EBAZ2BALDH1A1POLB
SCHEMBL222289 0.78 BAZ2B (0.63) HCAR2DAOKDM4EGRNSORT1
SCHEMBL70171 0.78 KDM4E (0.58) HCAR2HCAR3DAOKDM4EGRN
SCHEMBL537448 0.78 MALT1 (0.41) KDM4EGRNSORT1BAZ2BALDH1A1
SCHEMBL295558 0.78 MAPK1 (0.42) KDM4EBAZ2BALDH1A1POLBGAA
SCHEMBL5879683 0.77 KDM4E (0.39) HCAR2DAOKDM4EGRNSORT1
SCHEMBL22235052 0.77 KDM4E (0.39) HCAR2DAOKDM4EGRNSORT1
SCHEMBL1313309 0.77 KDM4E (0.39) HCAR2DAOKDM4EGRNSORT1
SCHEMBL16468579 0.77 RPA1 (0.40) KDM4EGRNSORT1BAZ2BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024153155-A1 DOUBLE-HETEROCYCLIC WRN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 成都微芯药业有限公司 2024-07-25 WO disclosed
US-20230159521-A1 1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) VERTEX PHARMACEUTICALS INCORPORATED 2023-05-25 US disclosed
US-20230159521-A1 1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) VERTEX PHARMACEUTICALS INCORPORATED 2023-05-25 US disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11174219-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2021-11-16 US disclosed
WO-2021203025-A1 1 H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1 H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD) VERTEX PHARMACEUTICALS INCORPORATED (US) 2021-10-07 WO disclosed
CN-112979550-A Method for preparing 1-methyl-5-hydroxypyrazole by using microchannel reactor 山东亿盛实业股份有限公司 2021-06-18 CN disclosed
US-20210155576-A1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP, LLC (US) 2021-05-27 US disclosed
US-10829438-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2020-11-10 US disclosed
US-10315984-B2 Neprilysin inhibitors THERAVANCE BIOPHARMA R&D IP, LLC (US) 2019-06-11 US disclosed
WO-2008047071-A1 TRISAZO-DYES WITH A PYRAZOLYL END GROUP AND THEIR USE IN INK-JET PRINTING FUJIFILM IMAGING COLORANTS LIMITED (GB) 2008-04-24 WO disclosed
WO-2008047071-A1 TRISAZO-DYES WITH A PYRAZOLYL END GROUP AND THEIR USE IN INK-JET PRINTING FUJIFILM IMAGING COLORANTS LIMITED (GB) 2008-04-24 WO disclosed
EP-1131299-B1 METHOD FOR PRODUCING 1-SUBSTITUTED 5- OR 3-HYDROXYPYRAZOLES BASF AG (DE) 2003-09-17 EP disclosed
EP-1131298-B1 METHOD FOR THE PRODUCTION OF 1-SUBSTITUTED 5-HYDROXYPYRAZOLES BASF AG (DE) 2003-09-03 EP disclosed
US-20030109717-A1 Preparation of substituted hydroxypyrazoles GOTZ NORBERT (DE) 2003-06-12 US disclosed
US-6472538-B1 HIGH YIELD COUPLING, HYDROGENATION AND CYCLIZATION TO FORM CHEMICAL INTERMEDIATES FOR HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 2002-10-29 US disclosed
US-6392058-B1 REACTING AN ALKYL VINYL ETHER WITH PHOSGENE; FORMING ACYL CHLORIDE; ESTERIFICATION; REACTING WITH HYDRAZINE BASF AKTIENGESELLSCHAFT (DE) 2002-05-21 US disclosed
US-6329530-B1 REACTING ALKYL VINYL ETHER WITH PHOSGENE OR PHOSGENE DERIVATIVE TO FORM ACYL CHLORIDE DERIVATIVE; DEHYDROCHLORIANTING TO FORM 3-ALKOXYACRYLOYL CHLORIDE COMPOUND; REACTING WITH ALKYLHYDRAZINE BASF AKTIENGESELLSCHAFT (DE) 2001-12-11 US disclosed
US-5464860-A Antiepileptic agents NOVAPHARME (FR) 1995-11-07 US disclosed
US-5258397-A FOR TREATMENT OF EPILEPSY; SIDE EFFECT REDUCTION NOVAPHARME (FR) 1993-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11174219-B2 Neprilysin inhibitors MME, REN, ACE HCAR2 845/4885HCAR3 443/4885DAO 1404/4885
US-10829438-B2 Neprilysin inhibitors MME, REN, ACE HCAR2 845/4885HCAR3 443/4885DAO 1404/4885
US-20210155576-A1 NEPRILYSIN INHIBITORS MME, REN, ACE HCAR2 845/4885HCAR3 443/4885DAO 1404/4885
US-20030109717-A1 Preparation of substituted hydroxypyrazoles CYC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS HCAR2 400/4885HCAR3 236/4885DAO 2333/4885
US-10315984-B2 Neprilysin inhibitors MME, REN, ACE HCAR2 845/4885HCAR3 443/4885DAO 1404/4885
US-20230159521-A1 1H-PYRAZOLO[4,3-G]ISOQUINOLINE AND 1H-PYRAZOLO[4,3-G]QUINOLINE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD) SERPINA2, SERPINE1, SERPINA3 HCAR2 4489/4885HCAR3 4493/4885DAO 898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.