Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | PHPT1 | Q9NRX4 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Roxarsone SCHEMBL29485898 | 0.80 | MAPT (1.00) | LMNAMAPTKDM4EL3MBTL1CYP2C19 | |
| Roxarsone SCHEMBL28105454 | 0.80 | MAPT (1.00) | LMNAMAPTKDM4EL3MBTL1CYP2C19 | |
| Roxarsone SCHEMBL158026 | 0.80 | MAPT (1.00) | LMNAMAPTKDM4EL3MBTL1CYP2C19 | |
| Roxarsone SCHEMBL27915909 | 0.79 | MAPT (0.96) | LMNAMAPTKDM4EL3MBTL1CYP2C19 | |
| Roxarsone SCHEMBL20636782 | 0.79 | MAPT (0.96) | LMNAMAPTKDM4EL3MBTL1CYP2C19 | |
| SCHEMBL30986730 | 0.74 | CYP2C19 (0.50) | LMNAMAPTKDM4EL3MBTL1CYP2C19 | |
| SCHEMBL29385509 | 0.73 | ALDH1A1 (0.62) | LMNAMAPTALDH1A1HIF1AMEN1 | |
| SCHEMBL1187891 | 0.73 | ALDH1A1 (0.62) | LMNAMAPTALDH1A1HIF1AMEN1 | |
| SCHEMBL12625747 | 0.73 | ALDH1A1 (0.56) | LMNAMAPTALDH1A1HIF1AMEN1 | |
| SCHEMBL1858467 | 0.73 | ALDH1A1 (0.56) | LMNAMAPTALDH1A1HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228076-B1 | A SUBSTANTIALLY CELL MEMBRANE IMPERMEABLE COMPOUND AND USE THEREOF | NEWSOUTH INNOVATIONS PTY LTD (AU) | 2011-07-06 | — | — | EP | disclosed |