Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.51 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL563300 | 0.77 | ADORA2B (0.63) | ADORA2APNPADORA2B | |
| SCHEMBL21530641 | 0.71 | MPO (0.63) | ADORA2A | |
| SCHEMBL21530744 | 0.71 | ADORA2A (0.48) | ADORA2AADORA2B | |
| SCHEMBL21530676 | 0.71 | ADORA2A (0.48) | ADORA2AADORA2B | |
| SCHEMBL6362812 | 0.69 | PNP (0.48) | PNP | |
| SCHEMBL21530648 | 0.69 | ADORA2A (1.00) | ADORA2AADORA2B | |
| SCHEMBL21530667 | 0.69 | ADORA2A (1.00) | ADORA2AADORA2B | |
| SCHEMBL7099892 | 0.68 | ADORA2A (0.47) | ADORA2AADORA2B | |
| SCHEMBL1170110 | 0.68 | TLR8 (1.00) | TLR8 | |
| SCHEMBL16512990 | 0.68 | TLR8 (0.71) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213112-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2022-07-07 | — | — | US | disclosed |
| US-20220213112-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2022-07-07 | — | — | US | disclosed |
| US-11220510-B2 | Pyrrole tricyclic compounds as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2022-01-11 | — | — | US | disclosed |
| US-11220510-B2 | Pyrrole tricyclic compounds as A2A / A2B inhibitors | INCYTE CORPORATION (US) | 2022-01-11 | — | — | US | disclosed |
| US-20190337957-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2019-11-07 | — | — | US | disclosed |
| US-20190337957-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | INCYTE CORPORATION | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190337957-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | ADORA2A, ADORA2B, ADORA1 | ADORA2A 1/4885TLR8 1764/4885PNP 279/4885 |
| US-20220213112-A1 | PYRROLE TRICYCLIC COMPOUNDS AS A2A / A2B INHIBITORS | ADORA2A, ADORA2B, ADORA1 | ADORA2A 1/4885TLR8 1764/4885PNP 279/4885 |
| US-11220510-B2 | Pyrrole tricyclic compounds as A2A / A2B inhibitors | ADORA2A, ADORA2B, ADORA1 | ADORA2A 1/4885TLR8 1764/4885PNP 279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.