SCHEMBL2153079

SCHEMBL2153079

Nc1nc(Cl)c2ncn(CC(=O)O)c2n1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 6/20 0.56
HDAC1 Q13547 5/20 0.56
HDAC4 P56524 1/20 0.56
HSP90AB1 P08238 11/20 0.52
HSP90AA1 P07900 10/20 0.52
HDAC2 Q92769 1/20 0.50
P2RX7 Q99572 1/20 0.49
CYP2C19 P33261 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30052313 0.86 CDK1 (0.62) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL1672138 0.86 CDK1 (0.62) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL9388321 0.84 CYP2C19 (0.47) HDAC6HDAC1HDAC4CYP2C19
SCHEMBL7872842 0.83 HSP90AB1 (0.55) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL8649570 0.81 HSP90AB1 (0.55) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL8768015 0.80 HSP90AB1 (0.52) HSP90AB1HSP90AA1CYP2C19
SCHEMBL31058755 0.80 HDAC6 (0.54) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL8839795 0.80 HDAC6 (0.52) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL19245704 0.80 HSP90AB1 (0.56) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1
SCHEMBL27854926 0.80 CDK1 (0.71) HDAC6HDAC1HDAC4HSP90AB1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4551210-A1 BIFACIAL PEPTIDE NUCLEIC ACID PROBES AND METHODS OF USING THEREOF Ohio State Innovation Foundation (US) 2025-05-14 EP disclosed
WO-2024010977-A1 BIFACIAL PEPTIDE NUCLEIC ACID PROBES AND METHODS OF USING THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2024-01-11 WO disclosed
CN-107447215-B Etching solution composition for copper-based metal film and method of manufacturing array substrate for liquid crystal display device using the same 东友精细化工有限公司 2021-06-22 CN disclosed
CN-106148961-A Etching agent composite, formation metal line pattern method and manufacturing array substrate approach 东友精细化工有限公司 2016-11-23 CN disclosed
US-20120115136-A1 PNA DIAGNOSTIC USE PNA Patent Owners (a/k/a CIG) (US) 2012-05-10 US disclosed
US-8012956-B2 Tropane compounds EXELIXIS, INC. (US) 2011-09-06 US disclosed
EP-1074559-B1 Peptide nucleic acids BUCHARDT OLE (DK) 2011-07-06 EP disclosed
CN-101910168-A Tropane compounds EXELIXIS INC 2010-12-08 CN disclosed
EP-2074120-B1 TROPANE COMPOUNDS EXELIXIS INC (US) 2010-03-03 EP disclosed
EP-2074120-A1 TROPANE COMPOUNDS Exelixis, Inc. (US) 2009-07-01 EP disclosed
US-5539082-A Peptide nucleic acids NIELSEN PETER E (DK) 1996-07-23 US disclosed
WO-1996020212-A2 PEPTIDE NUCLEIC ACID INCORPORATING A CHIRAL BACKBONE BUCHARDT, DORTE (DK) 1996-07-04 WO disclosed
WO-1996011205-A9 PEPTIDE NUCLEIC ACID CONJUGATES 1996-05-30 WO disclosed
WO-1996011205-A1 PEPTIDE NUCLEIC ACID CONJUGATES ISIS PHARMACEUTICALS, INC. (US) 1996-04-18 WO disclosed
WO-1996002558-A1 LINKED PEPTIDE NUCLEIC ACIDS ISIS PHARMACEUTICALS, INC. (US) 1996-02-01 WO disclosed
WO-1994012213-A1 METHOD OF PRODUCING ANTIBODIES WITH CONJUGATES OF B-CELL-ANTIGEN AND DENATURED CARRIER BUCHARDT OLE (DK) 1994-06-09 WO disclosed
EP-0586618-A1 THE USE OF NUCLEIC ACID ANALOGUES IN DIAGNOSTICS AND ANALYTICAL PROCEDURES. BUCHARDT OLE (DK) 1994-03-16 EP disclosed
EP-0586474-A1 PEPTIDE NUCLEIC ACIDS BUCHARDT, Ole (DK) 1994-03-16 EP disclosed
WO-1992020703-A1 THE USE OF NUCLEIC ACID ANALOGUES IN DIAGNOSTICS AND ANALYTICAL PROCEDURES BUCHARDT OLE (DK) 1992-11-26 WO disclosed
WO-1992020702-A1 PEPTIDE NUCLEIC ACIDS BUCHARDT OLE (DK) 1992-11-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120115136-A1 PNA DIAGNOSTIC USE RNASE1, NCL, PABPC4 HDAC6 1949/4885HDAC1 4277/4885HDAC4 2868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.