SCHEMBL2153177

SCHEMBL2153177

Nc1ccc(-c2ccc(N)c(Cl)c2)cc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 9/20 0.77
ALDH1A1 P00352 5/20 0.77
TSHR P16473 5/20 0.77
MAPK1 P28482 1/20 0.77
ESR2 Q92731 2/20 0.69
TDP1 Q9NUW8 5/20 0.52
TP53 P04637 2/20 0.52
HSD17B10 Q99714 3/20 0.52
THRB P10828 2/20 0.52
HPGD P15428 2/20 0.52
ALOX15 P16050 2/20 0.52
CASP1 P29466 1/20 0.52
RECQL P46063 1/20 0.52
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
GAA P10253 2/20 0.49
KDM4E B2RXH2 1/20 0.49
NPC1 O15118 1/20 0.49
USP2 O75604 1/20 0.49
LMNA P02545 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzidine SCHEMBL16243713 1.00 CYP3A4 (0.77) CYP3A4ALDH1A1TSHRMAPK1ESR2
Benzidine SCHEMBL3059403 0.98 CYP3A4 (0.82) CYP3A4ALDH1A1TSHRMAPK1ESR2
Benzidine SCHEMBL1660896 0.98 CYP3A4 (0.82) CYP3A4ALDH1A1TSHRMAPK1ESR2
SCHEMBL23137319 0.93 CYP3A4 (0.90) CYP3A4ALDH1A1TSHRMAPK1ESR2
SCHEMBL8872306 0.90 CYP3A4 (0.94) CYP3A4ALDH1A1TSHRMAPK1ESR2
SCHEMBL29365311 0.90 CYP3A4 (0.94) CYP3A4ALDH1A1TSHRMAPK1ESR2
SCHEMBL49382 0.90 CYP3A4 (0.94) CYP3A4ALDH1A1TSHRMAPK1ESR2
Benzidine SCHEMBL2917004 0.88 ALDH1A1 (0.72) CYP3A4ALDH1A1TSHRMAPK1ESR2
Hydrochloric Acid SCHEMBL29368557 0.87 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRMAPK1ESR2
Hydrochloric Acid SCHEMBL30242948 0.87 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRMAPK1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12209168-B2 Polyurethane foam premixes containing halogenated olefin blowing agents and foams made from same HONEYWELL INTERNATIONAL INC. (US) 2025-01-28 US claimed
WO-2006067380-A1 MARKING OF PIPES UPONOR INNOVATION AB (SE) 2006-06-29 WO claimed
EP-0541510-B1 Wholly aromatic polyamide copolymer TEIJIN LTD (JP) 1996-09-18 EP claimed
US-5006629-A Excellent heat, fire, chemical resistance; spinning and shaping stability; superior mechanical strength TEIJIN LIMITED (JP) 1991-04-09 US claimed
EP-0367535-A1 Wholly aromatic polyamide copolymer TEIJIN LIMITED (JP) 1990-05-09 EP claimed
JP-2229827-A None JP disclosed
US-12209168-B2 Polyurethane foam premixes containing halogenated olefin blowing agents and foams made from same HONEYWELL INTERNATIONAL INC. (US) 2025-01-28 US disclosed
US-11730717-B1 Melanin-inspired antimicrobial The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges (US) 2023-08-22 US disclosed
CN-113950498-B Bio-based polyurethane (meth) acrylates for coating 湛新比利时股份有限公司 2023-05-26 CN disclosed
US-20220228027-A1 BIOBASED URETHANE (METH)ACRYLATE FOR USE IN CLADDING ALLNEX BELGIUM S.A. (BE) 2022-07-21 US disclosed
CN-114746434-A Antibiotic compounds 莱顿大学 2022-07-12 CN disclosed
EP-3986948-A1 BIOBASED URETHANE (METH)ACRYLATE FOR USE IN CLADDING Allnex Belgium, S.A. (BE) 2022-04-27 EP disclosed
EP-0309392-A2 Mono- and dichloro-4,4'-diaminodiphenyl-5,5'-disulfonic acids CIBA-GEIGY AG (CH) 1989-03-29 EP disclosed
EP-0282855-A2 Pigment preparations BAYER AG (DE) 1988-09-21 EP disclosed
EP-0263481-A2 Process for the preparation of isocyanates BAYER AG (DE) 1988-04-13 EP disclosed
EP-0171588-A1 Chain-lengthening or cross-linking agent LONZA AG (CH) 1986-02-19 EP disclosed
US-4308311-A UNDERCOATING OF ALCOHOL-SOLUBLE POLYAMIDE; ADHESION; AUDIO AND VIDEO TAPES FUJI PHOTO FILM CO., LTD. (JP) 1981-12-29 US disclosed
US-4297099-A BY PENETRATION AND CROSSLINKING DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1981-10-27 US disclosed
EP-0005211-A2 Process for the preparation of 2,2'-dichlorohydrazobenzene CIBA-GEIGY AG (CH) 1979-11-14 EP disclosed
US-3939106-A Energy absorbing polyurethane-polyurea cellular elastomers UNION CARBIDE CORPORATION (US) 1976-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11730717-B1 Melanin-inspired antimicrobial TYR, MCHR1, EEA1 CYP3A4 3771/4885ALDH1A1 2565/4885TSHR 1773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.