Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.36 |
| ▸ | CACNG8 | Q8WXS5 | 4/20 | 0.36 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189354 | 0.86 | PGR (0.54) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21533269 | 0.81 | PGR (0.35) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21533225 | 0.79 | GRIA1 (0.52) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL18189617 | 0.71 | GRIA1 (0.58) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL18189534 | 0.68 | PGR (0.56) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL21533098 | 0.68 | PRMT5 (0.42) | PGRGRIA1CACNG8OTUD7BBRD4 | |
| SCHEMBL18189331 | 0.68 | GRIA1 (0.50) | PGRGRIA1CACNG8BRD4CREBBP | |
| SCHEMBL26021817 | 0.68 | AHR (0.61) | PGRAHR | |
| SCHEMBL18190651 | 0.68 | GRIA1 (0.71) | GRIA1CACNG8 | |
| SCHEMBL18189489 | 0.66 | GRIA1 (0.50) | PGRGRIA1CACNG8BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |