Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | OTUD7B | Q6GQQ9 | 4/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.36 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 4/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189599 | 0.87 | GRIA1 (0.52) | PRMT5WDR77OTUD7BGRIA1CACNG8 | |
| SCHEMBL18190607 | 0.70 | PRMT5 (0.47) | PRMT5WDR77GRIA1CACNG8IRAK4 | |
| SCHEMBL18189503 | 0.70 | GRIA1 (0.55) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL14124533 | 0.69 | TLK2 (0.38) | GRIA1BRD4 | |
| SCHEMBL21533221 | 0.68 | PGR (0.37) | OTUD7BGRIA1CACNG8PGRBRD4 | |
| SCHEMBL21533225 | 0.68 | GRIA1 (0.52) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL20111124 | 0.68 | GRIA1 (0.70) | PRMT5WDR77GRIA1CACNG8PGR | |
| SCHEMBL18189523 | 0.65 | GRIA1 (0.55) | GRIA1CACNG8PGRBRD4CREBBP | |
| SCHEMBL16960969 | 0.64 | VEGFA (0.41) | PRMT5WDR77IRAK4VEGFA | |
| SCHEMBL26021816 | 0.64 | PNMT (0.42) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |