Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.41 |
| ▸ | PGR | P06401 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189499 | 0.79 | GRIA1 (0.55) | AHRPGRGRIA1CACNG8CMA1 | |
| SCHEMBL18189657 | 0.75 | GRIA1 (0.53) | AHRPGRGRIA1CACNG8CMA1 | |
| SCHEMBL6904021 | 0.68 | AHR (0.53) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL10420660 | 0.68 | AHR (0.51) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL18669097 | 0.67 | AHR (0.51) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL3570265 | 0.67 | GRIA1 (0.49) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL24570672 | 0.66 | AHR (0.61) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL4551223 | 0.66 | AHR (0.49) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL8670836 | 0.66 | AHR (0.59) | AHRPGRMAOBGRIA1CACNG8 | |
| SCHEMBL24192175 | 0.66 | AHR (0.51) | AHRPGRMAOBGRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |