Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20813807 | 0.80 | PDE5A (0.42) | MEN1KMT2APDE5A | |
| SCHEMBL24392596 | 0.79 | PIK3CA (0.43) | MEN1KMT2APDE5APIK3CAPIK3R1 | |
| SCHEMBL20350896 | 0.79 | NQO2 (0.46) | MEN1KMT2APDE5AALDH1A1MAPT | |
| SCHEMBL12143431 | 0.75 | PDE5A (0.68) | PDE5APDE1B | |
| SCHEMBL22745039 | 0.73 | PIK3CA (0.48) | PIK3CAPIK3R1HDAC1PIK3CDPIK3CB | |
| SCHEMBL22745001 | 0.72 | PIK3CA (0.42) | PIK3CAPIK3R1HDAC1PIK3CDPIK3CB | |
| SCHEMBL22744980 | 0.71 | PIK3CA (0.53) | PIK3CAPIK3R1HDAC1 | |
| SCHEMBL11583026 | 0.70 | HTR1A (0.50) | ALDH1A1 | |
| SCHEMBL22732354 | 0.70 | PIK3CA (0.47) | PIK3CAPIK3R1HDAC1PIK3CDPIK3CB | |
| SCHEMBL13841363 | 0.70 | PDE5A (0.42) | MEN1KMT2APDE5AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560921-A1 | QUINAZOLINE COMPOUND AND PREPARATION METHOD, APPLICATION, AND PHARMACEUTICAL COMPOSTION THEREOF | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2019-10-30 | — | — | EP | disclosed |