Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28142303 | 1.00 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL29710686 | 1.00 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28261411 | 1.00 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL5874241 | 1.00 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL7399441 | 0.98 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL20972296 | 0.98 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL29192334 | 0.98 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL20972298 | 0.98 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL3914666 | 0.98 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28154636 | 0.98 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 325 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117362215-A | Method for extracting indole from coal tar wash oil | 辽宁科技学院 | 2024-01-09 | — | — | CN | claimed |
| WO-2023212494-A2 | PREDICTIVE PESTICIDE RESISTANCE INFORMATION GENERATION AND USE | PIONEER HI-BRED INTERNATIONAL, INC. (US) | 2023-11-02 | — | — | WO | claimed |
| WO-2023148487-A1 | FUNGICIDAL COMBINATIONS | UPL Corporation Limited (MU) | 2023-08-10 | — | — | WO | claimed |
| CN-113176253-B | Occult blood indicator for animal excrement and application thereof | 上海麦可信生物科技有限公司 | 2023-05-23 | — | — | CN | claimed |
| CN-113176253-A | Animal excrement occult blood indicator and application thereof | 上海麦可信生物科技有限公司 | 2021-07-27 | — | — | CN | claimed |
| CN-111982878-A | Water pollution analysis method based on ultraviolet visible spectrum and three-dimensional fluorescence spectrum | 安徽思环科技有限公司 | 2020-11-24 | — | — | CN | claimed |
| CN-111100631-A | Multicolor luminous solid silicon dot powder and multifunctional application of preparation method thereof | 华南农业大学 | 2020-05-05 | — | — | CN | claimed |
| CN-110511182-A | A kind of method of continuous flow reaction synthesis 7- nitro -1,2,3,4- tetrahydroquinoline | SHANGHAI SYNCHEM PHARMA CO LTD | 2019-11-29 | — | — | CN | claimed |
| CN-105198861-B | 6- acyl group -1,2,4- triazine -3,5- derovatives and herbicide | FMC公司 | 2019-11-22 | — | — | CN | claimed |
| CN-108844937-A | A kind of water soluble fluorescence silicon point and preparation method thereof and application | 福建中医药大学 | 2018-11-20 | — | — | CN | claimed |
| CN-108793875-A | A kind of modified coal ash enhancing concrete | 枞阳县天筑新型建筑材料有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-108520982-A | A kind of electrolyte for lead-acid accumulator | 童振锴 | 2018-09-11 | — | — | CN | claimed |
| CN-106336338-A | Method for removing quinoline in DMNO-3 | 上海宝钢化工有限公司 | 2017-01-18 | — | — | CN | claimed |
| CN-103110632-B | Composition for treating nosemosis of bees and preparation method thereof | QINGDAO LVMAN BIOLOGICAL ENGINEERING CO., LTD. (CN) | 2014-10-22 | — | — | CN | claimed |
| CN-103110632-A | Pure traditional Chinese medicine composition for treating nosemosis of bees and preparation method thereof | QINGDAO LVMAN BIOLOG ENG CO | 2013-05-22 | — | — | CN | claimed |
| CN-101679272-B | Triazolo [1, 5-a] quinolines as adenosine A3 receptor ligands | SANOFI AVENTIS | 2013-02-06 | — | — | CN | claimed |
| CN-101679272-A | Triazolo [1,5-A] quinoline as the adenosine A 3 receptor part | SANOFI AVENTIS | 2010-03-24 | — | — | CN | claimed |
| CN-1431903-A | Minoxidil-containing preparations | TAISHO PHARMACEUTICAL CO LTD (JP) | 2003-07-23 | — | — | CN | claimed |
| US-4249604-A | Recovery method for high viscosity petroleum | TEXACO INC. (US) | 1981-02-10 | — | — | US | claimed |
| US-3986833-A | TEST COMPOSITION, DEVICE, AND METHOD FOR THE DETECTION OF PEROXIDATIVELY ACTIVE SUBSTANCES | MILES LABORATORIES, INC. (US) | 1976-10-19 | — | — | US | claimed |