Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11480037 | 0.81 | KDM4E (0.54) | TP53POLBRXFP1THRBMAPT | |
| SCHEMBL11480030 | 0.80 | KDM4E (0.53) | TP53POLBRXFP1THRBMAPT | |
| SCHEMBL3924265 | 0.77 | HIF1A (0.63) | TP53POLBRXFP1MAPTMEN1 | |
| SCHEMBL14644998 | 0.72 | POLB (0.57) | TP53POLBMAPTNPC1RAB9A | |
| SCHEMBL12210344 | 0.71 | POLB (0.56) | TP53POLBMAPTNPC1RAB9A | |
| SCHEMBL2951746 | 0.68 | ALDH1A1 (0.65) | POLBMAPTNPC1RAB9AMEN1 | |
| SCHEMBL16281239 | 0.65 | KDM4E (0.58) | POLBMAPTNPC1RAB9AMEN1 | |
| SCHEMBL20254473 | 0.65 | KMT2A (0.59) | TP53POLBRXFP1THRBMAPT | |
| SCHEMBL14625798 | 0.64 | LIMK1 (0.71) | MAPTKDM4EHPGDPKMNPSR1 | |
| SCHEMBL14090705 | 0.64 | KDM4E (0.57) | POLBMAPTNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | Zacharon Pharmaceutical, Inc. (US) | 2012-11-22 | — | — | US | disclosed |
| WO-2011082175-A2 | GLYCOSAMINOGLYCAN INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20100048638-A1 | HEPARAN SULFATE INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100048638-A1 | HEPARAN SULFATE INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| WO-2010003023-A2 | HEPARAN SULFATE INHIBITORS | ZACHARON PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295890-A1 | GLYCOSAMINOGLYCAN INHIBITORS | CSGALNACT1, FUT5, ST3GAL3 | TP53 3840/4885POLB 4591/4885RXFP1 1637/4885 |
| US-20100048638-A1 | HEPARAN SULFATE INHIBITORS | HPSE, ENGASE, CSGALNACT1 | TP53 4477/4885POLB 4581/4885RXFP1 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.