Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439916 | 0.87 | GRM6 (0.40) | GRM6KDM4ECISD2ALDH1A1LMNA | |
| SCHEMBL27719113 | 0.86 | KDM4E (0.49) | GRM6KDM4ECISD2ALDH1A1LMNA | |
| SCHEMBL4033414 | 0.77 | ALDH1A1 (0.41) | GRM6KDM4ECISD2ALDH1A1LMNA | |
| SCHEMBL27682582 | 0.77 | ALDH1A1 (0.50) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| Ethane SCHEMBL27400512 | 0.76 | GRM6 (0.39) | GRM6KDM4ECISD2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4105337 | 0.75 | TDP1 (0.39) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL20303097 | 0.74 | ALDH1A1 (0.42) | KDM4EALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL27805811 | 0.72 | GRM6 (0.40) | GRM6KDM4ECISD2ALDH1A1LMNA | |
| SCHEMBL27580623 | 0.72 | GRM6 (0.43) | GRM6CISD2ALDH1A1LMNAKMT2A | |
| SCHEMBL21543939 | 0.71 | CISD2 (0.44) | CISD2ALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240158357-A1 | NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | OLIGOMERIX, INC. (US) | 2024-05-16 | — | — | US | disclosed |
| EP-4252856-A2 | NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | Oligomerix, Inc. (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-3558950-B1 | NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | OLIGOMERIX INC (US) | 2023-05-10 | — | — | EP | disclosed |
| CN-114213400-B | Thiophene-containing pyrimidine compound and preparation method and application thereof | 贵州大学 | 2022-11-08 | — | — | CN | disclosed |
| US-11472776-B2 | Quinazolinones that inhibit the formation of tau oligomers and their method of use | OLIGOMERIX, INC. (US) | 2022-10-18 | — | — | US | disclosed |
| CN-114213400-A | Thiophene-containing pyrimidine compound and preparation method and application thereof | 贵州大学 | 2022-03-22 | — | — | CN | disclosed |
| US-20190345115-A1 | NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | OLIGOMERIX, INC. | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345115-A1 | NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | MAPT, PSEN1, APP | GRM6 3041/4885KDM4E 3341/4885CISD2 1925/4885 |
| US-11472776-B2 | Quinazolinones that inhibit the formation of tau oligomers and their method of use | MAPT, PSEN1, APP | GRM6 3444/4885KDM4E 2885/4885CISD2 2327/4885 |
| US-20240158357-A1 | NOVEL QUINAZOLINONES THAT INHIBIT THE FORMATION OF TAU OLIGOMERS AND THEIR METHOD OF USE | MAPT, PSEN1, APP | GRM6 3041/4885KDM4E 3341/4885CISD2 1925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.