Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21313483 | 0.82 | MAPT (0.50) | MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20363223 | 0.77 | KDM4E (0.41) | POLBKDM4ENFKB1MAPTMEN1 | |
| SCHEMBL7666283 | 0.76 | POLA1 (0.60) | KDM4ENFKB1PIK3CAMTORSYK | |
| SCHEMBL655538 | 0.72 | SYK (0.68) | POLBKDM4ENFKB1MAPTMEN1 | |
| SCHEMBL14820063 | 0.72 | MAPT (0.49) | KDM4EMAPTMEN1KMT2APIK3CA | |
| SCHEMBL7672313 | 0.71 | POLA1 (0.38) | POLBKDM4ENFKB1MAPTMEN1 | |
| SCHEMBL7672177 | 0.71 | CCNE1 (0.44) | POLBKDM4ENFKB1MEN1KMT2A | |
| SCHEMBL20962582 | 0.71 | MAPT (0.47) | KDM4EMAPTMEN1KMT2APIK3CA | |
| SCHEMBL14805630 | 0.69 | MAPT (0.46) | KDM4EMAPTMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL28689142 | 0.69 | MAPT (0.46) | KDM4EMAPTMEN1KMT2APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190345154-A1 | NOVEL PYRIMIDINE DERIVATIVE HAVING ANTIMALARIAL ACTIVITY | CARNA BIOSCIENCES, INC. (JP) | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345154-A1 | NOVEL PYRIMIDINE DERIVATIVE HAVING ANTIMALARIAL ACTIVITY | UMPS, TYMS, TYMP | POLB 535/4885KDM4E 2402/4885NFKB1 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.