Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 5/20 | 0.60 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.45 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20363223 | 0.82 | KDM4E (0.41) | POLA1CDK2PIK3CAMTORCDK1 | |
| SCHEMBL21544599 | 0.76 | POLB (0.49) | PIK3CAMTORSYKKDM4ENFKB1 | |
| SCHEMBL5779077 | 0.74 | POLA1 (0.60) | POLA1CDK2NEK2SYK | |
| SCHEMBL8539783 | 0.74 | CDK2 (0.64) | POLA1CDK2NEK2CCNT1CDK1 | |
| SCHEMBL7672313 | 0.72 | POLA1 (0.38) | POLA1CDK2PIK3CAMTORKDM4E | |
| SCHEMBL7672177 | 0.68 | CCNE1 (0.44) | CDK2KDM4ENFKB1 | |
| SCHEMBL27824249 | 0.66 | DPP4 (0.61) | POLA1CDK2 | |
| SCHEMBL20363222 | 0.66 | MEN1 (0.35) | POLA1PIK3CAMTORKDM4ENFKB1 | |
| SCHEMBL9278629 | 0.66 | POLA1 (0.59) | POLA1CDK2CDK1CCNB1 | |
| Alcohol SCHEMBL27897029 | 0.65 | DPP4 (0.54) | POLA1CDK2CDK1CCNB1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414147-B1 | DIAGNOSIS AND TREATMENT OF ANXIETY, DEPRESSION, SLEEP AND SEIZURE DISORDERS, DOWN'S SYNDROME, OVERDOSE WITH BENZODIAZEPINE DRUGS, AND FOR ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |