SCHEMBL2154599

SCHEMBL2154599

O=[P](c1ccccc1)c1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
CYP1A2 P05177 1/20 0.46
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
LMNA P02545 2/20 0.40
CYP2A6 P11509 1/20 0.40
TDP1 Q9NUW8 2/20 0.39
CYP3A4 P08684 1/20 0.39
ORAI1 Q96D31 1/20 0.38
ORAI2 Q96SN7 1/20 0.38
ORAI3 Q9BRQ5 1/20 0.38
TRPV6 Q9H1D0 1/20 0.38
ALOX15 P16050 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.36
MAPT P10636 1/20 0.36
NR4A1 P22736 1/20 0.36
ESR1 P03372 2/20 0.36
ESR2 Q92731 2/20 0.36
RAB9A P51151 1/20 0.34
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1304998 0.89 LMNA (0.50) TSHRCYP1A2CES2CES1LMNA
SCHEMBL1666 0.84 TDP1 (0.53) TSHRCES2CES1LMNACYP2A6
SCHEMBL28556505 0.81 TDP1 (0.50) TSHRCES2CES1LMNACYP2A6
SCHEMBL28831553 0.81 TDP1 (0.50) TSHRCES2CES1LMNACYP2A6
SCHEMBL2154496 0.79 NPC1 (0.42) TSHRLMNATDP1MAPTRAB9A
SCHEMBL31189346 0.79 NPC1 (0.42) TSHRLMNATDP1MAPTRAB9A
SCHEMBL2454269 0.79 CYP3A4 (0.67) TSHRCYP1A2CES2CES1LMNA
SCHEMBL8773581 0.79 CYP3A4 (0.67) TSHRCYP1A2CES2CES1LMNA
SCHEMBL28443581 0.78 CES2 (0.50) TSHRCES2CES1LMNACYP2A6
SCHEMBL2154438 0.77 TSHR (0.50) TSHRCYP1A2CES2CES1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104761717-A Polyaryletherketone quadripolymer and preparation method thereof CHANGCHUN APPLIED CHEMISTRY 2015-07-08 CN claimed
CN-104725987-A Coating combination and metal material CHANGCHUN APPLIED CHEMISTRY 2015-06-24 CN claimed
CN-103073586-A Double (3-sulfonic acid-4-chlorophenyl)-3'-sulfoacid phenyl phosphine oxide and preparation method of salt thereof UNIV TIANJIN NORMAL 2013-05-01 CN claimed
CN-103073587-A 3-sulfonic group-4-halophenyl-3'-sulfophenyl-4''-halophenylphosphine oxide and preparation method of salt thereof UNIV TIANJIN NORMAL 2013-05-01 CN claimed
CN-101723978-B Sulfonated phosphine oxide monomer and efficient preparation method of salt thereof UNIV TIANJIN NORMAL 2012-01-04 CN claimed
CN-101723978-A Sulfonated phosphine oxide monomer and efficient preparation method of salt thereof UNIV TIANJIN NORMAL 2010-06-09 CN claimed
CN-101445601-A Sulfonated polyarylether based on triphenylphosphine oxide structure unit and preparation method thereof UNIV SHANGHAI JIAOTONG (CN) 2009-06-03 CN claimed
CN-1195004-C Sulfonated poly phenyl thioether ketone-like ionomer and its preparation method UNIV SHANGHAI JIAOTONG (CN) 2005-03-30 CN claimed
CN-1410473-A Sulfonated poly phenyl thioether ketone-like ionomer and its preparation method UNIV SHANGHAI JIAOTONG (CN) 2003-04-16 CN claimed
CN-119613454-A Preparation method of difluoromethyl-containing compound 昆明理工大学 2025-03-14 CN disclosed
CN-119431439-A Method for preparing 2-formylaryl (phosphinic) phosphine/phosphoramide compound 岳阳凯茂化工材料有限公司 2025-02-14 CN disclosed
CN-115403623-B Method for preparing 2-pyrrolyl substituted phosphine oxide compound 湖南理工学院 2024-10-29 CN disclosed
CN-116284126-A Diaryl phosphono-4-fluoro-3-butene-1-one compound and preparation method thereof 南京工业大学 2023-06-23 CN disclosed
CN-110256489-B Preparation method of alkyl phosphonyl 苏州大学 2022-03-08 CN disclosed
CN-101723978-B Sulfonated phosphine oxide monomer and efficient preparation method of salt thereof UNIV TIANJIN NORMAL 2012-01-04 CN disclosed
WO-2011082192-A1 PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-07-07 WO disclosed
CN-101723978-A Sulfonated phosphine oxide monomer and efficient preparation method of salt thereof UNIV TIANJIN NORMAL 2010-06-09 CN disclosed
CN-101445601-A Sulfonated polyarylether based on triphenylphosphine oxide structure unit and preparation method thereof UNIV SHANGHAI JIAOTONG (CN) 2009-06-03 CN disclosed
CN-1195004-C Sulfonated poly phenyl thioether ketone-like ionomer and its preparation method UNIV SHANGHAI JIAOTONG (CN) 2005-03-30 CN disclosed
CN-1410473-A Sulfonated poly phenyl thioether ketone-like ionomer and its preparation method UNIV SHANGHAI JIAOTONG (CN) 2003-04-16 CN disclosed