SCHEMBL21546636

SCHEMBL21546636

N#Cc1cccc(-c2cc(-n3c4ccc(-c5cccc(-c6ccccc6)n5)cc4c4cc(-c5cccc(-c6ccccc6)n5)ccc43)c(-n3c4ccc(-c5cccc(-c6ccccc6)n5)cc4c4cc(-c5cccc(-c6ccccc6)n5)ccc43)cc2C#N)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 1/20 0.43
GABRA1 P14867 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA5 P31644 1/20 0.39
GABRA3 P34903 1/20 0.39
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
ADORA2A P29274 2/20 0.37
GRM2 Q14416 1/20 0.37
MAOB P27338 1/20 0.37
ADORA1 P30542 1/20 0.36
IDO1 P14902 1/20 0.36
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2C19 P33261 2/20 0.35
KMT2A Q03164 2/20 0.35
CLK4 Q9HAZ1 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546505 0.97 ALDH1A3 (0.41) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL21546661 0.93 ALDH1A3 (0.42) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL21546506 0.91 ALDH1A3 (0.43) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL19919814 0.91 ALDH1A3 (0.46) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL21546503 0.91 ALDH1A3 (0.41) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22760717 0.91 ALDH1A3 (0.41) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL21546690 0.90 ALDH1A3 (0.42) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562224 0.89 ALDH1A3 (0.37) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22760965 0.89 PGR (0.41) ALDH1A3MEN1ALDH1A1CYP1A2CYP3A4
SCHEMBL19919815 0.89 ALDH1A3 (0.43) ALDH1A3GABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed