SCHEMBL21546723

SCHEMBL21546723

Cc1ccc2c3ccc(C)cc3n(-c3cc(-c4cccc(C#N)c4)cc(-n4c5cc(C)ccc5c5ccc(C)cc54)c3C#N)c2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 3/20 0.36
ADORA1 P30542 3/20 0.36
ADORA2B P29275 2/20 0.36
CLK4 Q9HAZ1 2/20 0.36
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 2/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
CYP2C9 P11712 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
MAPK1 P28482 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
ALDH1A3 P47895 1/20 0.36
GRIA2 P42262 1/20 0.35
GRIA4 P48058 1/20 0.35
IDO1 P14902 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546721 0.95 ADORA2A (0.36) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL21546791 0.93 CYP1A2 (0.39) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL21546819 0.93 GRIA2 (0.39) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL22760924 0.90 SYK (0.37) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL21546808 0.90 ADORA2A (0.36) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL22761070 0.89 CLK4 (0.40) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL21547016 0.89 MAP4K4 (0.40) ADORA2AADORA1ADORA2BCLK4ALDH1A1
SCHEMBL21414261 0.89 USP14 (0.35) ALDH1A1LMNA
SCHEMBL21546821 0.89 PGR (0.35) CLK4ALDH1A1CYP1A2KDM4ELMNA
SCHEMBL22822537 0.87 GRM5 (0.40) ALDH1A1LMNAPGRXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed