SCHEMBL21546728

SCHEMBL21546728

Cc1cccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(C#N)cc(-n3c4ccccc4c4cc(-c5cccc(C)c5)ccc43)c2-c2cccc(C#N)c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
CYP1A2 P05177 5/20 0.39
LMNA P02545 2/20 0.39
CYP2C9 P11712 2/20 0.39
TSHR P16473 2/20 0.39
MAPK1 P28482 2/20 0.39
HSD17B10 Q99714 2/20 0.39
KDM4E B2RXH2 1/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PTGER4 P35408 1/20 0.39
ALDH1A3 P47895 1/20 0.37
CYP3A4 P08684 4/20 0.37
CLK4 Q9HAZ1 4/20 0.37
ELANE P08246 1/20 0.36
MAP4K4 O95819 1/20 0.36
SIRT2 Q8IXJ6 2/20 0.36
AR P10275 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21414127 0.95 PTGER4 (0.37) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL22760889 0.94 ALDH1A3 (0.37) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546727 0.93 MCHR1 (0.38) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546744 0.93 MAP4K4 (0.40) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21414267 0.91 MAP4K4 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546785 0.91 MAP4K4 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546583 0.91 ALDH1A3 (0.40) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL24737204 0.90 CYP1A2 (0.40) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546948 0.90 PTGER4 (0.37) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546620 0.90 CYP1A2 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed