SCHEMBL21546727

SCHEMBL21546727

Cc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(C#N)cc(-n3c4ccccc4c4cc(-c5ccc(C)cc5)ccc43)c2-c2cccc(C#N)c2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.38
ALDH1A3 P47895 1/20 0.37
PTGER4 P35408 1/20 0.37
PDE9A O76083 1/20 0.37
PDE1C Q14123 1/20 0.37
GRIA2 P42262 1/20 0.37
GRIA4 P48058 1/20 0.37
ALDH1A1 P00352 5/20 0.37
CYP1A2 P05177 5/20 0.37
CYP3A4 P08684 4/20 0.37
CLK4 Q9HAZ1 4/20 0.37
MAP4K4 O95819 1/20 0.36
PTPN5 P54829 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
USP2 O75604 1/20 0.35
HIF1A Q16665 1/20 0.35
LMNA P02545 2/20 0.35
CYP2C9 P11712 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21546946 0.95 CYP1A2 (0.39) MCHR1ALDH1A3GRIA2GRIA4ALDH1A1
SCHEMBL21546477 0.94 MCHR1 (0.37) MCHR1ALDH1A3PDE9APDE1CGRIA2
SCHEMBL21414129 0.94 PDE9A (0.39) PTGER4PDE9APDE1CALDH1A1LMNA
SCHEMBL21546728 0.93 ALDH1A1 (0.39) ALDH1A3PTGER4GRIA2GRIA4ALDH1A1
SCHEMBL21414267 0.93 MAP4K4 (0.39) ALDH1A3PTGER4GRIA2GRIA4ALDH1A1
SCHEMBL21546583 0.93 ALDH1A3 (0.40) ALDH1A3GRIA2GRIA4ALDH1A1CYP1A2
SCHEMBL21546744 0.93 MAP4K4 (0.40) ALDH1A3PTGER4GRIA2GRIA4ALDH1A1
SCHEMBL22760889 0.92 ALDH1A3 (0.37) ALDH1A3PTGER4GRIA2GRIA4ALDH1A1
SCHEMBL21546475 0.92 PTGER4 (0.39) ALDH1A3PTGER4GRIA2GRIA4ALDH1A1
SCHEMBL21546785 0.91 MAP4K4 (0.39) ALDH1A3PTGER4GRIA2GRIA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed