SCHEMBL21546790

SCHEMBL21546790

Cc1cccc(-c2ccc3c4ccccc4n(-c4cc(-c5cccc(C#N)c5)cc(-n5c6ccccc6c6ccc(-c7cccc(C)c7)cc65)c4C#N)c3c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.37
CYP1A2 P05177 4/20 0.37
LMNA P02545 2/20 0.37
CYP2C9 P11712 2/20 0.37
TSHR P16473 2/20 0.37
MAPK1 P28482 2/20 0.37
HSD17B10 Q99714 2/20 0.37
KDM4E B2RXH2 1/20 0.37
TP53 P04637 1/20 0.37
HPGD P15428 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
ALDH1A3 P47895 1/20 0.37
KDM4A O75164 1/20 0.36
KDM5B Q9UGL1 1/20 0.36
ELANE P08246 1/20 0.36
AR P10275 2/20 0.35
ADORA2A P29274 3/20 0.35
ADORA1 P30542 3/20 0.35
ADORA2B P29275 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21414279 0.96 KDM4A (0.36) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546791 0.95 CYP1A2 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546789 0.93 ALDH1A1 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546721 0.93 ADORA2A (0.36) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21414280 0.91 KDM4A (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL22760924 0.91 SYK (0.37) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546840 0.91 ADORA2A (0.37) ALDH1A3ADORA2AADORA1ADORA2BGRIA2
SCHEMBL19919668 0.89 ADORA2A (0.38) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL21546819 0.89 GRIA2 (0.39) ALDH1A1CYP1A2LMNACYP2C9TSHR
SCHEMBL22761058 0.89 CYP1A2 (0.41) ALDH1A1CYP1A2LMNACYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3478793-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-11-06 EP disclosed