SCHEMBL21414280

SCHEMBL21414280

Cc1cccc(-c2ccc3c4ccc(-c5cccc(C)c5)cc4n(-c4cc(-c5cc(C#N)cc(C#N)c5)cc(-n5c6cc(-c7cccc(C)c7)ccc6c6ccc(-c7cccc(C)c7)cc65)c4C#N)c3c2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4A O75164 1/20 0.39
KDM5B Q9UGL1 1/20 0.39
AR P10275 1/20 0.38
GRIA2 P42262 1/20 0.36
GRIA4 P48058 1/20 0.36
PIP4K2A P48426 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35
GRM5 P41594 1/20 0.35
ALDH1A1 P00352 3/20 0.35
HPGD P15428 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CYP2C9 P11712 2/20 0.35
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21414279 0.95 KDM4A (0.36) KDM4AKDM5BARGRIA2GRIA4
SCHEMBL21546791 0.95 CYP1A2 (0.39) KDM4AKDM5BARGRIA2GRIA4
SCHEMBL21414184 0.91 KDM5B (0.38) KDM4AKDM5BGRM5PGR
SCHEMBL21546790 0.91 ALDH1A1 (0.37) KDM4AKDM5BARGRIA2GRIA4
SCHEMBL22760924 0.90 SYK (0.37) KDM4AKDM5BARGRIA2GRIA4
SCHEMBL20617091 0.90 AR (0.43) KDM4AKDM5BARGRIA2GRIA4
SCHEMBL21546684 0.90 MAP4K4 (0.39) GRIA2GRIA4ADORA2AADORA1ALDH1A1
SCHEMBL21414288 0.90 MAP4K4 (0.39) GRIA2GRIA4ADORA2AADORA1ALDH1A1
SCHEMBL21414171 0.89 CHEK1 (0.36) ARGRM5ALDH1A1HPGDKDM4E
SCHEMBL21414287 0.88 PGR (0.36) PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3385264-B1 ORGANIC MOLECULES, IN PARTICULAR FOR THE APPLICATION IN ORGANIC OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2019-10-02 EP disclosed