Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23716291 | 0.85 | ALDH1A1 (0.39) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| SCHEMBL21427813 | 0.84 | HTT (0.46) | ALDH1A1LMNACYP1A2TSHRKDM4E | |
| SCHEMBL22872467 | 0.79 | HRH1 (0.50) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| SCHEMBL18576871 | 0.77 | TDP1 (0.53) | ALDH1A1CYP1A2SMN1; SMN2TDP1TSHR | |
| SCHEMBL22703058 | 0.76 | MAPT (0.55) | ALDH1A1CYP1A2SMN1; SMN2TDP1TSHR | |
| SCHEMBL22854000 | 0.75 | KDM4E (0.38) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| SCHEMBL24072727 | 0.74 | TDP1 (0.46) | ALDH1A1CYP1A2SMN1; SMN2TDP1TSHR | |
| SCHEMBL21872596 | 0.74 | HRH1 (0.52) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| SCHEMBL16938329 | 0.73 | ALDH1A1 (0.39) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| SCHEMBL24081274 | 0.71 | HRH3 (0.40) | HRH3HRH1ALDH1A1LMNATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564234-A1 | NMDA ANTAGONIST PRODRUGS | AstraZeneca AB (SE) | 2019-11-06 | — | — | EP | disclosed |