Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CRHR1 | P34998 | 8/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356749 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTCRHR1P2RX7TLR7 | |
| Hydrochloric Acid SCHEMBL21526020 | 0.84 | SMN1; SMN2 (0.42) | SMN1; SMN2HTTCRHR1P2RX7TLR7 | |
| SCHEMBL21548891 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2HTTP2RX7MEN1KMT2A | |
| SCHEMBL21548811 | 0.76 | HTT (0.46) | SMN1; SMN2HTTP2RX7MEN1KMT2A | |
| SCHEMBL21548936 | 0.76 | MAPT (0.48) | SMN1; SMN2HTTMEN1KMT2AKDM4E | |
| SCHEMBL21526073 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2HTTCRHR1P2RX7KDM4E | |
| Hydrochloric Acid SCHEMBL21526127 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTCRHR1P2RX7KDM4E | |
| Hydrochloric Acid SCHEMBL21526024 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTP2RX7KDM4ELMNA | |
| SCHEMBL21548809 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2HTTP2RX7KDM4ELMNA | |
| SCHEMBL28322161 | 0.70 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTP2RX7KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |