Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 13/20 | 0.47 |
| ▸ | TSHR | P16473 | 12/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21526096 | 0.88 | KDM4C (0.44) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL21548932 | 0.84 | MAPT (0.43) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| Tert-Butyl Formate SCHEMBL28322155 | 0.80 | CYP1A2 (0.47) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL21548802 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2HTTLMNAMEN1KMT2A | |
| SCHEMBL23955999 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1HSD17B10SMN1; SMN2HTTLMNA | |
| SCHEMBL29439607 | 0.74 | CYP1A2 (0.50) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL22715975 | 0.74 | CYP1A2 (0.50) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL21548891 | 0.74 | SMN1; SMN2 (0.73) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL4918798 | 0.72 | CYP1A2 (0.47) | MAPTCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL21548811 | 0.71 | HTT (0.46) | MAPTCYP1A2CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |