Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356565 | 0.83 | NPSR1 (0.40) | HTTNPSR1ALDH1A1KDM4ELMNA | |
| SCHEMBL21548888 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2HTTALDH1A1KDM4ELMNA | |
| SCHEMBL21548936 | 0.76 | MAPT (0.48) | SMN1; SMN2HTTNPSR1ALDH1A1KDM4E | |
| SCHEMBL21548891 | 0.75 | SMN1; SMN2 (0.73) | SMN1; SMN2HTTALDH1A1KDM4ELMNA | |
| SCHEMBL20356658 | 0.74 | NPSR1 (0.37) | SMN1; SMN2HTTNPSR1CRHR1ALDH1A1 | |
| SCHEMBL21526039 | 0.74 | HTT (0.46) | SMN1; SMN2HTTNPSR1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL21526047 | 0.74 | NPSR1 (0.37) | SMN1; SMN2HTTNPSR1CRHR1ALDH1A1 | |
| SCHEMBL21548879 | 0.73 | HTT (0.45) | SMN1; SMN2HTTNPSR1SLC6A4ALDH1A1 | |
| SCHEMBL25398607 | 0.71 | SLC6A4 (0.43) | SMN1; SMN2SLC6A4HTR2AKCNH2KDM4E | |
| SCHEMBL3783737 | 0.70 | HTT (0.50) | SMN1; SMN2HTTSLC6A4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |