Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21548843 | 0.90 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL23956009 | 0.81 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL21526023 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL21548807 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL21548876 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL21548942 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL21548901 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1ENPP1HTTADORA2A | |
| SCHEMBL21526092 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1ENPP1HTTMAPT | |
| SCHEMBL21548891 | 0.71 | SMN1; SMN2 (0.73) | SMN1; SMN2ALDH1A1HTTMAPTL3MBTL1 | |
| SCHEMBL28811623 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1ENPP1MAPTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |