Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SLC26A6 | Q9BXS9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21548832 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL21548842 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL21526023 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL21548841 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL21526021 | 0.78 | SLC26A6 (0.54) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL21526117 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1LMNAMAPTTP53 | |
| SCHEMBL21526092 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL21548943 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1ENPP1LMNAMAPT | |
| SCHEMBL21526045 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1ENPP1PDE3BPDE3A | |
| SCHEMBL20356703 | 0.68 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1ENPP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| US-11034659-B2 | Pyrimidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-06-15 | — | — | US | disclosed |
| US-20200172494-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-06-04 | — | — | US | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034659-B2 | Pyrimidine derivative | GPR39, CFTR, TMEM109 | SMN1; SMN2 2983/4885ALDH1A1 3457/4885ENPP1 3364/4885 |
| US-20200172494-A1 | PYRIMIDINE DERIVATIVE | GPR39, CFTR, TMEM109 | SMN1; SMN2 2983/4885ALDH1A1 3457/4885ENPP1 3364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.