Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20356705 | 0.81 | MAPT (0.40) | SMN1; SMN2ALDH1A1HTTCASP3SENP8 | |
| SCHEMBL21548901 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1ADORA2AADORA1ENPP1 | |
| SCHEMBL21548943 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1ADORA2AADORA1ENPP1 | |
| SCHEMBL21548843 | 0.74 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ADORA2AADORA1ENPP1 | |
| SCHEMBL20356703 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1ENPP1HTTCASP3 | |
| SCHEMBL5258778 | 0.70 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1ADORA2AADORA1ENPP1 | |
| SCHEMBL21548886 | 0.67 | GRM4 (0.35) | SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL23956009 | 0.67 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1ADORA2AADORA1ENPP1 | |
| SCHEMBL7816199 | 0.65 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1ENPP1IDO1CYP1A2 | |
| SCHEMBL20356647 | 0.65 | SLC26A6 (0.40) | SMN1; SMN2ALDH1A1ADORA2AADORA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-B1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2021-10-27 | — | — | EP | disclosed |
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |