Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 8/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.64 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | CCNH | P51946 | 1/20 | 0.58 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.58 |
| ▸ | DHFR | P00374 | 1/20 | 0.55 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20416390 | 0.81 | CDK7 (0.66) | CDK7CCNHMNAT1 | |
| SCHEMBL16075920 | 0.79 | CLK1 (0.71) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL29488123 | 0.79 | CLK1 (0.71) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL20691183 | 0.79 | CLK1 (0.71) | CLK1CDK5CDK5R1MAP3K14GSK3B | |
| SCHEMBL17150733 | 0.79 | CDK5 (0.71) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL24839575 | 0.79 | CLK1 (0.71) | CLK1CDK5CDK5R1MAP3K14GSK3B | |
| SCHEMBL23336396 | 0.76 | CDK7 (0.72) | CDK7CCNHMNAT1 | |
| SCHEMBL21026876 | 0.75 | CDK5 (0.69) | CLK1CDK5CDK5R1CDK7CCNH | |
| SCHEMBL24839810 | 0.75 | CLK1 (0.66) | CLK1CDK5CDK5R1MAP3K14GSK3B | |
| SCHEMBL24839576 | 0.74 | CDK7 (1.00) | CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10865206-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2020-12-15 | — | — | US | disclosed |
| US-20190337940-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190337940-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | CLK1 254/4885CDK5 10/4885CDK5R1 40/4885 |
| US-10865206-B2 | Inhibitors of cyclin-dependent kinase 7 (CDK7) | CDK7, CDK3, CDK9 | CLK1 254/4885CDK5 10/4885CDK5R1 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.