Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 9/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.66 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.66 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.55 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16075920 | 0.80 | CLK1 (0.71) | CLK1CDK5CDK5R1CCNT1CCNK | |
| SCHEMBL17150733 | 0.80 | CDK5 (0.71) | CLK1CDK5CDK5R1CCNT1CCNK | |
| SCHEMBL20691183 | 0.80 | CLK1 (0.71) | CLK1CDK5CDK5R1MAP3K14GSK3B | |
| SCHEMBL24839575 | 0.80 | CLK1 (0.71) | CLK1CDK5CDK5R1CCNT1CCNK | |
| SCHEMBL29488123 | 0.80 | CLK1 (0.71) | CLK1CDK5CDK5R1CCNT1CCNK | |
| SCHEMBL21026876 | 0.76 | CDK5 (0.69) | CLK1CDK5CDK5R1CCNT1CCNK | |
| SCHEMBL21549456 | 0.75 | CLK1 (0.64) | CLK1CDK5CDK5R1MAP3K14GSK3B | |
| SCHEMBL29488162 | 0.69 | GSK3B (1.00) | CLK1CDK5CDK5R1CCNT1CDK2 | |
| SCHEMBL12922475 | 0.69 | CDK5 (0.56) | CLK1CDK5CDK5R1MAP3K14GSK3B | |
| SCHEMBL29700410 | 0.69 | CDK5 (0.60) | CLK1CDK5CDK5R1MAP3K14GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| US-20230000870-A1 | METHODS OF TREATING CANCER IN BIOMARKER-IDENTIFIED PATIENTS WITH INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000870-A1 | METHODS OF TREATING CANCER IN BIOMARKER-IDENTIFIED PATIENTS WITH INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, RB1, MKI67 | CLK1 835/4885CDK5 21/4885CDK5R1 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.