Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9926762 | 0.93 | HDAC1 (0.39) | HDAC1HDAC2HDAC4HDAC6LMNA | |
| SCHEMBL21549646 | 0.86 | HDAC1 (0.35) | HDAC1HDAC2HDAC4HDAC6LMNA | |
| SCHEMBL12533282 | 0.83 | ALDH1A1 (0.40) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL4348222 | 0.78 | HDAC1 (0.39) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL29353376 | 0.78 | HDAC1 (0.37) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL18726574 | 0.78 | HDAC1 (0.37) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL574827 | 0.78 | HDAC1 (0.37) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL31005440 | 0.78 | HDAC1 (0.39) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL9904994 | 0.77 | HDAC1 (0.36) | HDAC1HDAC2LMNAALDH1A1EHMT2 | |
| SCHEMBL15159491 | 0.76 | EHMT2 (0.37) | HDAC1HDAC2ALDH1A1EHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3188733-B1 | CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS | IMMUNOGEN INC (US) | 2019-11-06 | — | — | EP | disclosed |