Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15185771 | 0.80 | DHODH (0.45) | NPSR1NPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL14030746 | 0.76 | MAPK14 (0.50) | NPSR1NPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL91488 | 0.76 | HRH4 (0.50) | NPSR1NPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL91471 | 0.70 | MAPK14 (0.39) | NPSR1NPC1RAB9AMAPTCYP2C9 | |
| SCHEMBL91474 | 0.70 | MAPK14 (0.41) | NPSR1NPC1SMN1; SMN2RAB9ATP53 | |
| SCHEMBL91405 | 0.68 | HRH4 (0.55) | NPSR1NPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL14629467 | 0.68 | HTR7 (0.57) | MAPK14 | |
| SCHEMBL22201928 | 0.66 | ALDH1A1 (0.47) | SMN1; SMN2TP53MAPTLMNAALOX15 | |
| SCHEMBL13218581 | 0.66 | HRH4 (0.43) | NPSR1NPC1SMN1; SMN2PKMRAB9A | |
| SCHEMBL91468 | 0.66 | HRH4 (0.46) | NPSR1SMN1; SMN2MAPTCYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3194383-B1 | QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS INC (US) | 2019-11-06 | — | — | EP | disclosed |