Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2955843 | 0.86 | MMP12 (0.54) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL18152757 | 0.80 | MMP12 (0.49) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL24286262 | 0.80 | MMP12 (0.49) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL305188 | 0.80 | MMP12 (0.57) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL8192799 | 0.80 | NR3C2 (0.51) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL18264334 | 0.77 | MMP12 (0.49) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7670635 | 0.77 | MMP12 (0.49) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3342717 | 0.77 | MMP12 (0.49) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL1853066 | 0.77 | MMP12 (0.57) | MMP12PARP1ALDH1A1KMT2AMAPT | |
| SCHEMBL5914785 | 0.77 | NR3C2 (0.51) | MMP12PARP1ALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3790551-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2021-03-17 | — | — | EP | disclosed |
| WO-2019217307-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-11-14 | — | — | WO | disclosed |
| WO-2019217307-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2019-11-14 | — | — | WO | disclosed |