Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18264334 | 0.93 | MMP12 (0.49) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL30015636 | 0.93 | MMP12 (0.49) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL2945700 | 0.86 | MMP12 (0.54) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL2955843 | 0.86 | MMP12 (0.54) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL18152757 | 0.80 | MMP12 (0.49) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL3342717 | 0.80 | MMP12 (0.49) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL8192799 | 0.80 | NR3C2 (0.51) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL3592276 | 0.80 | MMP12 (0.49) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL21552385 | 0.80 | MMP12 (0.49) | MMP12PARP1MAPTALDH1A1TP53 | |
| SCHEMBL305188 | 0.80 | MMP12 (0.57) | MMP12PARP1MAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |