Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 6/20 | 0.51 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31633370 | 1.00 | KCNH2 (0.51) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| SCHEMBL32677386 | 0.89 | HTR1A (0.53) | KCNH2HTR7HTR1AHTR2AHTR6 | |
| SCHEMBL31633369 | 0.88 | HTR7 (0.49) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| SCHEMBL21552597 | 0.88 | HTR7 (0.49) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| SCHEMBL21552678 | 0.88 | HTR7 (0.49) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| SCHEMBL32677385 | 0.88 | HTR7 (0.49) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| SCHEMBL21552618 | 0.88 | HTR7 (0.49) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| SCHEMBL29950431 | 0.88 | HTR7 (0.49) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| Hydrochloric Acid SCHEMBL23363931 | 0.87 | HTR7 (0.48) | KCNH2HTR7HTR1ASIGMAR1HTR2A | |
| Hydrochloric Acid SCHEMBL23363929 | 0.87 | HTR7 (0.48) | KCNH2HTR7HTR1ASIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3790859-A1 | NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE | Temple University - Of The Commonwealth System of Higher Education (US) | 2021-03-17 | — | — | EP | disclosed |
| WO-2019217890-A1 | NOVEL FUNCTIONALIZED LACTAMS AS MODULATORS OF THE 5-HYDROXYTRYPTAMINE RECEPTOR 7 AND THEIR METHOD OF USE | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-11-14 | — | — | WO | disclosed |