SCHEMBL21552644

SCHEMBL21552644

Oc1c(Cl)ccc(Br)c1O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.41
DPP4 P27487 1/20 0.41
HSD17B10 Q99714 4/20 0.36
CYP3A4 P08684 4/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
MAPK1 P28482 1/20 0.36
TSHR P16473 4/20 0.35
ALDH1A1 P00352 4/20 0.35
TDP1 Q9NUW8 3/20 0.35
CXCR1 P25024 1/20 0.34
CXCR2 P25025 1/20 0.34
HPGD P15428 2/20 0.33
RECQL P46063 2/20 0.33
MAPT P10636 2/20 0.33
TTR P02766 1/20 0.33
CASP1 P29466 1/20 0.33
KDM4E B2RXH2 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28414394 0.82 CA1 (0.47) ARHSD17B10CYP3A4CA1CA2
SCHEMBL30363595 0.82 CA1 (0.47) ARHSD17B10CYP3A4CA1CA2
SCHEMBL2935032 0.82 DPP4 (0.52) DPP4HSD17B10CYP3A4CA1CA2
SCHEMBL1223626 0.81 HSD17B10 (0.40) ARDPP4HSD17B10CYP3A4MAPK1
SCHEMBL16815458 0.81 CYP3A4 (0.46) ARDPP4HSD17B10CYP3A4CA1
SCHEMBL16045266 0.77 AR (0.38) ARDPP4HSD17B10CYP3A4MAPK1
SCHEMBL20873035 0.77 CDC7 (0.40) ARDPP4HSD17B10CYP3A4CA1
SCHEMBL22892769 0.77 AR (0.38) ARDPP4HSD17B10CYP3A4MAPK1
SCHEMBL118745 0.77 MEP1A (0.40) ARDPP4HSD17B10CYP3A4MAPK1
SCHEMBL2050332 0.77 AR (0.38) ARDPP4HSD17B10CYP3A4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250250269-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. 2025-08-07 US disclosed
US-20250109148-A1 HETEROCYCLIC GLP-1 AGONISTS SHANGHAI SHOUTI BIOTECHNOLOGY CO., LTD. (CN) 2025-04-03 US disclosed
EP-4508047-A1 HETEROCYCLIC GLP-1 AGONISTS Gasherbrum Bio, Inc. (US) 2025-02-19 EP disclosed
CN-119343339-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-01-21 CN disclosed
CN-119255988-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-01-03 CN disclosed
EP-4469444-A1 HETEROCYCLIC GLP-1 AGONISTS Gasherbrum Bio, Inc. (US) 2024-12-04 EP disclosed
CN-112135521-B 4-amino-6- (1, 3-benzodioxole) picolinic acid esters and their use as herbicides 科迪华农业科技有限责任公司 2024-03-29 CN disclosed
EP-3790389-B1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2024-02-28 EP disclosed
EP-3790389-B1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2024-02-28 EP disclosed
WO-2023198140-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO, INC. (US) 2023-10-19 WO disclosed
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides DOW AGROSCIENCES LLC 2023-08-08 US disclosed
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides DOW AGROSCIENCES LLC 2023-08-08 US disclosed
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides DOW AGROSCIENCES LLC 2023-08-08 US disclosed
WO-2023138684-A1 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO , INC. (US) 2023-07-27 WO disclosed
US-20210230147-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2021-07-29 US disclosed
US-20210230147-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2021-07-29 US disclosed
EP-3790389-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2021-03-17 EP disclosed
CN-112135521-A 4-amino-6- (1, 3-benzodioxole) picolinates and their use as herbicides 美国陶氏益农公司 2020-12-25 CN disclosed
WO-2019217617-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2019-11-14 WO disclosed
WO-2019217617-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2019-11-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250109148-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, GCGR AR 938/4885DPP4 15/4885HSD17B10 862/4885
US-11718604-B2 4-amino-6-(1,3-benzodioxole)picolinates and their use as herbicides ABAT, DAO, HPD AR 4019/4885DPP4 53/4885HSD17B10 2397/4885
US-20250250269-A1 HETEROCYCLIC GLP-1 AGONISTS GLP1R, GIPR, IAPP AR 851/4885DPP4 17/4885HSD17B10 1048/4885
US-20210230147-A1 4-AMINO-6-(1,3-BENZODIOXOLE)PICOLINATES AND THEIR USE AS HERBICIDES ABAT, DAO, HPD AR 4019/4885DPP4 53/4885HSD17B10 2397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.