SCHEMBL21552935

SCHEMBL21552935

O=c1c(N2CCS(O)(O)CC2)nc(Br)cn1Cc1ccc(F)cc1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 3/20 0.39
CNR1 P21554 2/20 0.39
SRC P12931 3/20 0.38
FLT3 P36888 3/20 0.38
FYN P06241 2/20 0.38
HDAC6 Q9UBN7 10/20 0.38
FAAH O00519 1/20 0.37
ABHD12 Q8N2K0 1/20 0.37
MAPT P10636 1/20 0.37
THRB P10828 1/20 0.37
SOS1 Q07889 1/20 0.37
PIK3CA P42336 2/20 0.36
PIK3CD O00329 1/20 0.36
PIK3CB P42338 1/20 0.36
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21552937 0.89 ALDH1A1 (0.43) CNR2CNR1SRCFLT3FYN
SCHEMBL21552841 0.86 HDAC6 (0.48) SRCFLT3FYNHDAC6SOS1
SCHEMBL21564669 0.83 SRC (0.39) CNR2CNR1SRCFLT3FYN
SCHEMBL21553020 0.82 L3MBTL1 (0.44) CNR2CNR1HDAC6FAAHABHD12
SCHEMBL21552820 0.81 ALDH1A1 (0.35) CNR2CNR1SRCFLT3FYN
SCHEMBL21564668 0.81 SRC (0.44) CNR2CNR1SRCFLT3FYN
SCHEMBL21552886 0.80 ABL1 (0.43) CNR2CNR1SRCFLT3FYN
SCHEMBL21552912 0.76 MAPT (0.47) CNR2CNR1FAAHABHD12MAPT
SCHEMBL21553001 0.75 SRC (0.33) SRCFLT3FYNHDAC6SOS1
SCHEMBL21564673 0.73 CYP11B1 (0.42) SRCFLT3FYNHDAC6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790867-B1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES INC (US) 2024-03-27 EP disclosed
US-11932629-B2 KDM1A inhibitors for the treatment of disease IMAGO BIOSCIENCES, INC. (US) 2024-03-19 US disclosed
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES INC (US) 2023-08-10 US disclosed
US-11578059-B2 KDM1A inhibitors for the treatment of disease Imago Biosciences. Inc. (US) 2023-02-14 US disclosed
US-20210115023-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. 2021-04-22 US disclosed
EP-3790867-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE Imago Biosciences Inc. (US) 2021-03-17 EP disclosed
WO-2019217972-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE IMAGO BIOSCIENCES, INC. (US) 2019-11-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11932629-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A CNR2 4361/4885CNR1 4072/4885SRC 2429/4885
US-20230250090-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1B, KDM1A, KDM2A CNR2 4361/4885CNR1 4072/4885SRC 2429/4885
US-20210115023-A1 KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE KDM1A, KDM1B, KDM2A CNR2 4240/4885CNR1 3707/4885SRC 2381/4885
US-11578059-B2 KDM1A inhibitors for the treatment of disease KDM1B, KDM1A, KDM2A CNR2 4361/4885CNR1 4072/4885SRC 2429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.