Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.47 |
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709301 | 0.75 | MKNK1 (0.43) | MKNK1MKNK2PDE10ACA12CA1 | |
| SCHEMBL11929832 | 0.75 | PDE10A (0.50) | MKNK1MKNK2PDE10ACA12CA1 | |
| SCHEMBL20769878 | 0.75 | SYK (0.47) | MKNK1MKNK2PDE10ACA12CA1 | |
| SCHEMBL21554403 | 0.74 | MKNK1 (0.74) | MKNK1MKNK2 | |
| SCHEMBL21554504 | 0.73 | MKNK1 (0.66) | MKNK1MKNK2PDE10ARXRAGRIN1 | |
| SCHEMBL21554458 | 0.72 | MKNK1 (0.53) | MKNK1MKNK2LMNA | |
| SCHEMBL27312847 | 0.70 | RAB9A (0.56) | ALDH1A1SYKATM | |
| SCHEMBL10272586 | 0.68 | HIF1A (0.57) | CA12CA1CA2CA9HRH3 | |
| SCHEMBL12301168 | 0.68 | CA12 (0.47) | CA12CA1CA2CA9HRH3 | |
| Metyridine SCHEMBL30481621 | 0.68 | HRH1 (0.55) | CA12CA1CA2CA9HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564235-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | Northwestern University (US) | 2019-11-06 | — | — | EP | disclosed |