Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.66 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21554444 | 0.90 | MKNK1 (0.68) | MKNK1MKNK2PDE10AKRASRPS6KA5 | |
| SCHEMBL21554502 | 0.81 | MKNK1 (0.88) | MKNK1MKNK2PDE10AGRIN1GRIN2B | |
| SCHEMBL21554403 | 0.80 | MKNK1 (0.74) | MKNK1MKNK2 | |
| SCHEMBL22722391 | 0.79 | MKNK1 (1.00) | MKNK1MKNK2GRIN1GRIN2BRXRA | |
| SCHEMBL21554500 | 0.73 | MKNK1 (0.68) | MKNK1MKNK2 | |
| SCHEMBL21554435 | 0.73 | MKNK1 (0.51) | MKNK1MKNK2PDE10AGRIN1GRIN2B | |
| SCHEMBL22722372 | 0.71 | MKNK1 (0.77) | MKNK1MKNK2 | |
| SCHEMBL22722381 | 0.67 | MKNK1 (1.00) | MKNK1MKNK2 | |
| SCHEMBL20479141 | 0.66 | MKNK1 (1.00) | MKNK1MKNK2RPS6KA5 | |
| SCHEMBL8709301 | 0.62 | MKNK1 (0.43) | MKNK1MKNK2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564235-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | Northwestern University (US) | 2019-11-06 | — | — | EP | disclosed |