Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860191 | 1.00 | CYP1A2 (0.46) | CYP1A2KDM4EGAAPDPK1CYP3A4 | |
| SCHEMBL627900 | 0.82 | GAA (0.45) | GAAHSD17B10ALDH1A1ALPLPOLB | |
| SCHEMBL31052682 | 0.82 | ALPL (0.46) | KDM4EGAAHPGDALDH1A1ALPL | |
| SCHEMBL628631 | 0.82 | ESR1 (0.47) | GAAPDPK1HSD17B10ALDH1A1ALPL | |
| SCHEMBL10112092 | 0.82 | GSK3A (0.38) | CYP1A2HPGDMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL2993163 | 0.81 | CYP1A2 (0.47) | CYP1A2KDM4EGAAPDPK1CYP3A4 | |
| SCHEMBL627442 | 0.78 | ALPL (0.49) | CYP1A2KDM4EGAACYP3A4HPGD | |
| SCHEMBL2634991 | 0.78 | MAP2K4 (0.45) | CYP1A2KDM4EPDPK1MAPK1CDK1 | |
| SCHEMBL30643584 | 0.77 | CYP1A2 (0.44) | CYP1A2KDM4EGAAPDPK1CYP3A4 | |
| SCHEMBL15995723 | 0.76 | TP53 (0.42) | MAPK1ALDH1A1TP53ALPLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432416-B1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER ITALIA SRL (IT) | 2011-01-19 | — | — | EP | claimed |
| EP-1820503-A2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | Pfizer Italia S.r.l. (IT) | 2007-08-22 | — | — | EP | claimed |
| CN-1556702-A | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | — | 2004-12-22 | — | — | CN | claimed |
| US-20040254177-A1 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2004-12-16 | — | — | US | claimed |
| EP-1432416-A1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pharmacia Italia S.p.A. (IT) | 2004-06-30 | — | — | EP | claimed |
| WO-2003028720-A1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2003-04-10 | — | — | WO | claimed |
| EP-0049779-B1 | 3-AMINOINDAZOLE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1984-10-31 | — | — | EP | claimed |
| EP-0049779-A1 | 3-Aminoindazole derivatives and process for preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-04-21 | — | — | EP | claimed |
| JP-58159470-A | — | — | None | — | — | JP | disclosed |
| JP-57053464-A | — | — | None | — | — | JP | disclosed |
| JP-58159469-A | — | — | None | — | — | JP | disclosed |
| JP-58159468-A | — | — | None | — | — | JP | disclosed |
| JP-58159473-A | — | — | None | — | — | JP | disclosed |
| US-8288396-B2 | Pyrimidopyrimidoindazole derivative | MSDKK (JP) | 2012-10-16 | — | — | US | disclosed |
| JP-S58159473-A | NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE HAVING SUBSTITUENT GROUP ON BENZEN RING AND ITS PREPARATION | ASAHI CHEM IND CO LTD | 1983-09-21 | — | — | JP | disclosed |
| JP-S58159470-A | NOVEL 3-AMINOINDAZOLE DERIVATIVE HAVING BRANCHED SIDE CHAIN AT 1-POSITION AND ITS PREPARATION | ASAHI CHEM IND CO LTD | 1983-09-21 | — | — | JP | disclosed |
| JP-S58159469-A | NOVEL 1,3-DISUBSTITUTED 3-AMINOINDAZOLE DERIVATIVE AND ITS PREPARATION | ASAHI CHEM IND CO LTD | 1983-09-21 | — | — | JP | disclosed |
| JP-S58159468-A | NOVEL 1-SUBSTITUTED 3-AMINOINDAZOLE DERIVATIVE AND ITS PREPARATION | ASAHI CHEM IND CO LTD | 1983-09-21 | — | — | JP | disclosed |
| EP-0049779-A1 | 3-Aminoindazole derivatives and process for preparation thereof | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-04-21 | — | — | EP | disclosed |
| JP-S5753464-A | NOVEL INDAZOLE DERIVATIVE | ASAHI CHEM IND CO LTD | 1982-03-30 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254177-A1 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them | MAP3K15, MAP3K3, MAP3K5 | CYP1A2 3946/4885KDM4E 1085/4885GAA 1209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.